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It doesn make you a good friend. And it certainly doesn make you a good teammate. And to me, they both important.”. However subsequent studies in Siberian hamsters and mice have suggested a catabolic role for the VGF derived peptide TLQP 21 (Bartolomucci et al., 2006; Jethwa et al., 2007). Thus the aim of this thesis was to further investigate the role of VGF in the regulation of energy homeostasis in the mouse and Siberian hamster. The studies presented in this thesis have shown that VGF derived peptide HHPD 41 can affect short term food intake in the Siberian hamsters, while overexpressing VGF mRNA in the hypothalamus of both Siberian hamsters and mice reduced bodyweight.
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