Masters thesis, Durham University
Mammals obtain nitrogen via the uptake of di and tri peptides in the gastrointestinal tract through the action of PepT1 and PepT2, which are members of the POT family of proton coupled oligopeptide transporters. PepT1 and PepT2 also play an important role in drug transport in the human body. Recent crystal structures of bacterial homologs revealed a conserved peptide binding site and mechanism of transport.
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